|
KMID : 0903520000430030174
|
|
Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2000 Volume.43 No. 3 p.174 ~ p.178
|
|
|
Searching of Cyclin - Dependent Kinase 4/Cyclin D1 Enzyme Inhibition Materials from the Native Plants
|
|
안병태/Ahn, Byung Tae
유시용/김미란/하지홍/성낙도/권병목/정하원/Ryu, Shi Yong/Kim, Mi Ran/Ha, Ji Hong/Sung, Nack Do/Kwon, Byung Mok/Chung, Ha Won
|
|
|
Abstract
|
|
|
|
To search CDK4/Cyclin D1 enzyme inhibition materials, methanol extracts of native eighty seven plant species in thirty seven families were screened in vitro for their inhibiting activities against CDK4/Cyclin D1 enzyme which are control to the normal cell division cycle in human body. Extracts of Paeonia suffruticosa, Saurus chinensis, Sanguisorba officinalis and Celastrus orbiculatus among them significantly inhibited above fifty percent (in 5 ㎍/㎖) against CDK4/ Cyclin D1 enzyme. Especially, the extracts of P. suffruticosaa and S. officinalis showed moderately strong inhibition. Also, cryptotanshinone was identified as active compound from a extracts of Salvia mitiorrhiza by spectroscopic analyses including 2D NMR experiments.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|